Enzyme-catalyzed amine-functionalization of poly(ethylene-glycol)
نویسندگان
چکیده
منابع مشابه
Enzyme-Catalyzed Modifications of Polysaccharides and Poly(ethylene glycol)
Polysaccharides are used extensively in various industrial applications, such as food, adhesives, coatings, construction, paper, pharmaceuticals, and personal care. Many polysaccharide structures need to be modified in order to improve their end-use properties; this is mostly done through chemical reactions. In the past 20 years many enzyme-catalyzed modifications have been developed to supplem...
متن کاملReduction-Triggered Breakable Micelles of Amphiphilic Polyamide Amine-g-Polyethylene Glycol for Methotrexate Delivery
Reduction-triggered breakable polymeric micelles incorporated with MTX were prepared using amphiphilic PAA-g-PEG copolymers having S-S bonds in the backbone. The micelles were spherical with diameters less than 70 nm. The micelles could encapsulate the hydrophobic MTX in the hydrophobic core. The drug loading content and drug loading efficiency of the micelles were highly dependent on the copol...
متن کاملBreathing life into polycations: functionalization with pH-responsive endosomolytic peptides and polyethylene glycol enables siRNA delivery.
siRNA has been widely used to identify gene functions and holds great potential in providing a new class of therapeutics.1 The lack of efficient delivery systems is limiting the full therapeutic potential of siRNA technology and represents a challenging hurdle in this field of therapy. For the purpose of nucleic acid transfer, among other synthetic carrier systems, polycations have been applied...
متن کاملStability of Trinitroglycerin in Polyethylene Glycol 400
In this study, the stability of trinitroglycerin (TNG) in polyethylene (PEG) 400 was investigated according to Arrhenius approach. The reaction rate constant (k) for the thermal disintegration of TNG in PEG 400 at various temperatures was counted based on the percents of remaining TNG at different intervals of time at a specific temperature. The results showed that “k” at 40, 50, 60, 70, 8...
متن کاملImmunogenicity of Polyethylene Glycol (PEG)
Covalent attachment of polyethylene glycol (PEG) to active proteins (PEGylation technology) successfully generated several FDA-approved compounds, including four blockbusters, which are considered non immunogenic. However, PEG antibodies and intolerance to the infusion were reported in some patients with gout treated with pegloticase, a PEG-uricase recently approved by the FDA (Food and Drug Ad...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Express Polymer Letters
سال: 2022
ISSN: ['1788-618X']
DOI: https://doi.org/10.3144/expresspolymlett.2022.68